Nov - Sohrab Shah¶
Speaker: Sohrab Shah
Talk Title: Mutation discovery in cancer using next generation sequencing and probabilistic models
Event Details
Date/Time:
November 26, 2009, 6:00pm **PLEASE NOTE THE DATE CHANGE**
Molecular Oncology Department, BC Cancer Agency
URL:
Sohrab Shah
Abstract:
The advent of next generation sequencing (NGS) has propelled the field of cancer
genomics forward such that it is now cost-effective to interrogate entire genomes or
transcriptomes of clinical tumor samples for the presence of somatic mutations: often
the key driver genomic alterations in tumorigenesis. Since the number of data points
produced by NGS experiments is in the billions, variant discovery is necessarily a
computational exercise. I will describe the development of novel computational methods
for the discovery of mutations from NGS, based on probabilistic models. I will present
results of applying these approaches in two recent studies in ovarian and breast cancer:
namely the discovery of a novel recurrent and defining mutation in the FOXL2 gene in
granulosa cell tumours of the ovary and the first description of mutational evolution of a
breast cancer seen at nucleotide resolution.
Presentation:
Download Presentation
Introductory Speaker:
Hye-Jung Elizabeth Chun, MSc Candidate
**Talk Title:**
Gene expression of breast tumors with different responses to immunotherapy
**Affiliation:**
[Bioinformatics Graduate Program, UBC](http://www.bioinformatics.ubc.ca/)
**Presentation:**
[Download Presentation:material-file-powerpoint-box:](https://drive.google.com/file/d/1IBCp5KH_9GBtA_1l9MCVSW9RVyMLfc8c/view?usp=sharing)
### The upcoming 2009-2010 meeting dates
December 10, 2009 Main Speaker: TBD; Intro Speaker: Rodrigo Goya, Marra Lab, Genome Sciences Centre, BCCA
January 13, 2010 **\*\*PLEASE NOTE THE DATE CHANGE\*\*** Main Speaker: [Evan Eichler](http://eichlerlab.gs.washington.edu/) , University of Washington; Intro Speaker: TBD
March 11, 2010 Main Speaker: [Rich Bonneau](http://homepages.nyu.edu/~rb133/) , New York University; Intro Speaker: TBD
April 8, 2010 Main Speaker: [Joerg Gsponer](http://www.chibi.ubc.ca/faculty/gsponer) , Centre for High-Throughput Biology; Intro Speaker: Kieran O’Neill, Brinkman Lab, BCCRC